Flow Chart Depicting Selection of…, Figure 1. more than the group who were asked to take a placebo. With that being said, there is growing evidence that alpha-lipoic acid can influence weight, albeit modestly. 2012 Oct;167(4):465-71. doi: 10.1530/EJE-12-0555. Study duration significantly affected BMI change, but not weight change. Alpha-lipoic acid supplementation reduces mTORC1 signalling in skeletal muscle from high fat fed, obese Zucker rats. 2020 Sep 30;29(3):163-165. doi: 10.7570/jomes20070. In the weight-loss studies alpha-lipoic acid supplementation combined with a low calorie diet. However, before using any supplements for your diet you should consult with your doctor first. Despite the positive research results, alpha-lipoic acid is not a miracle pill that will make you lose weight on its own.  |  Using alpha lipoic acid for weight loss is recommended as part of a balanced diet and adequate physical fitness regimen. Epub 2017 Jun 8. A new study conducted in Spain indicates that the dietary supplement alpha-lipoic acid (ALA) is both a safe and effective adjunct to calorie reduction in promoting weight loss. When united with a healthy diet and regular exercise, alpha-lipoic acid can help you lose more weight than without the supplementation. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant. Clin Nutr. Watanabe M, Risi R, Masi D, Caputi A, Balena A, Rossini G, Tuccinardi D, Mariani S, Basciani S, Manfrini S, Gnessi L, Lubrano C. Nutrients. Get the latest research from NIH: https://www.nih.gov/coronavirus. Results: Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. Group one took 1200 milligrams of alpha-lipoic acid per day (ALA-1200). Mean body weight differences between…, Figure 2. Studies indicate that alpha-lipoic acid may help you lose weight but they admit more research is needed and you might not have similar results with the supplementation as subjects in the study. See this image and copyright information in PMC. Alpha-lipoic acid may help you reduce weight. Some reported side effects included allergic skin reactions, itching, abdominal pain, nausea, vomiting and diarrhea. Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials. Alpha-lipoic acid treatment showed small, yet significant short-term weight loss compared with placebo. Alpha-Lipoic-Acid-300 (alpha-lipoic acid) for Dietary Supplementation: “AlA has stoped the tingling in my lower legs. R01 DK093924/DK/NIDDK NIH HHS/United States. and diagnosis or treatment. As you probably are already aware, weight gain and loss are more complex than a simple calories in/calories out model. 12 studies were analyzed and it was discovered that those who are taking the alpha-lipoic acid 300 mg supplements have lost an average of 1.52 lbs. Okanovic, A., Prnjavorac, B., Jusufovic, E., & Sejdinovic, R. (2015, July 9). Alpha lipoic acid (ALA) is a highly-potent antioxidant that is available as a dietary supplement. Epub 2017 Feb 26. Table IV.15: Evidence of Alpha Lipoic Acid's Weight Loss Effects; Dosage & Details Study Outcomes; 1200 or 1800 mg/day oral alpha lipoic acid in 400-600 mg doses 30 minutes before meals for 20 weeks, combined with a reduced calorie diet (no less than 1200 calories/day, 55-60% carbohydrates). Centers for Disease Control and Prevention: Obesity, Journal of Nutrition; Alpha-lipoic Acid and Cardiovascular Disease; Stephanie Wollin, et al. If you're vigorously exercising to shed pounds you're burning more oxygen — which creates more free radicals. The number of Alpha Lipoic Acid ability as an antioxidant, making Alpha Lipoic Acid is considered as a potent antioxidant. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. HHS advertisements are served by third party advertising companies. Alpha-lipoic acid; body mass; diabetes; thioctic acid. Maria Parepalo began writing professionally in 2006 and has published in medical journals as well as online. As long as you're healthy, the body can produce all the ALA it needs for these purposes. I've been using it for years in my practice. Body weight loss improved lipid and glucose metabolism parameters but without significant differences between groups. But the studies done on humans have shown that the alpha lipoic acid weight loss has only small effects. Alpha-Lipoic Acid: Weight Loss, Other Benefits and Side Effects Written by Ryan Raman, MS, RD Alpha-lipoic acid is an organic compound that acts as a powerful antioxidant in your body. , Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. ; 2011, Current Pharmaceutical Design; Alpha-lipoic Acid Supplementation: A Tool for Obesity Therapy; M.G. J Nutr. For example, it may help with appetite control. Even modest weight loss may be associated with health benefits. Another study published in "Current Pharmaceutical Design" in 2010, showed that a dose of 800 mg per day for four months cause a weight loss between 8 and 9 nine percent of body weight in obese or pre-obese teens.  |  Alpha-lipoic acid’s ability to enhance calorie burning and promote weight loss has been exaggerated by many diet gurus and supplements manufacturers. Alpha-lipoic acid reacts with oxygen radicals that protect cell membranes, protect against LDL oxidation and modulation of hypertension. Mendoza-Núñez VM, García-Martínez BI, Rosado-Pérez J, Santiago-Osorio E, Pedraza-Chaverri J, Hernández-Abad VJ. LIVESTRONG.com may earn compensation through affiliate links in this story. Epub 2020 Mar 26. New Data on Alpha Lipoic Acid. The supplement speeded up weight loss, as the figure below shows. Much of the research involving alpha-lipoic acid has been centered on the prevention of diabetes and the management of diabetic nerve pain. used as a substitute for professional medical advice, Several supplements that may help in weight loss are under research worldwide to help treat overweight and obese people. USA.gov. Obesity is a serious health condition that has been increasing considerably since the 1980s in the United States. Copyright Policy The various drugs used to promote weight loss, as well as many dietary supplements for the same, are fraught with both efficacy and safety issues. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse Endogenously synthesized lipoic acid is bound to protein and functions as a cofactor for several important mitochondrial multienzyme complexes. Please enable it to take advantage of the complete set of features! Alpha-lipoic acid reduces body weight and regulates … I had ben having electrical like tingling in lower legs … Weight Loss. 2020 Jul 2;11:694. doi: 10.3389/fphys.2020.00694. Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. After participants took 600 mg of the lipoic acid for a period of 24 weeks, “The data clearly showed a loss in body weight and body fat in people taking lipoic acid supplements,” said Balz Frei, director emeritus of OSU’s Linus Pauling Institute and one of the scientists on the study. 2019 Jun 12;2019:3276958. doi: 10.1155/2019/3276958. A systematic review of 12 clinical trials shows study participants supplementing with alpha-lipoic acid lost, on average, 1.52 pounds (0.69 kg) more than the placebo group. Int J Clin Pract. Alpha Lipoic Acid is a strong antioxidant that boosts the strength of vitamins C and E, and helps aid in the body’s energy production. In supplement form, it has long been taken to improve glucose sensitivity and treat diabetes, but more recently attention has moved to its potential for weight loss … Alpha-lipoic acid can help you lose weight according to scientific research. Let us see how it is connected to thyroid health and its effectiveness as a weight loss aid. Potential conflicts of interest: Authors report no competing interests, Figure 1. Meta-regression analysis showed no significance in ALA dose on BMI and weight changes. Leaf Group Ltd. Alpha-lipoic acid has also been researched as a treatment for many other conditions. And if you want to add EPA, I recommend taking it in the form of fish oil so that you get a dose of the essential fatty acid DHA at the same time. Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review. 2017 May;86(5):680-687. doi: 10.1111/cen.13303. Get the latest public health information from CDC: https://www.coronavirus.gov. Ninety-seven overweight or obese women were put on a weight loss-promoting calorie diet of 30% less than the total energy expenditure. ; 2010, PARTNER & LICENSEE OF THE LIVESTRONG FOUNDATION. Alpha-lipoic acid is an antioxidant and an essential co-factor needed for mitochondrial function. (More information) 3. What is Alpha Lipoic Acid? doi: 10.1111/ijcp.13493. Despite that fact, there has been a lot of recent interest in using ALA supplements. Objectives: Clipboard, Search History, and several other advanced features are temporarily unavailable. Use of this web site constitutes acceptance of the LIVESTRONG.COM Conclusions: Methods: Research has shown that alpha-lipoic acid may affect weight loss in several ways.. Before using alpha-lipoic acid for weight loss, talk to a medical doctor to ensure that it is safe (based on your medical status and medication or supplement regimen). Animal studies suggest that weight loss through alpha-lipoic acid is gained at the cost of lean body mass, but that was not the case in … Alpha Lipoic Acid can also aid in the breakdown of carbohydrates in the body - … Alpha lipoic acid has been proven to help with weight loss and thyroid health, primarily in women. In addition to neutralizing free radicals, Alpha Lipoic Acid can also bind to and disable heavy metals such as iron-free (free iron), cadmium, magnesium, copper, mercury, zinc, nickel, cobalt, arsenic, manganese and lead. A study published in the "American Journal of Medicine" in 2011, showed that obese people who took 1,800 mg of alpha-lipoic acid per day lost significantly more weight than people who used a placebo product. The second trial, this time from Korea, looked at the effect of two different doses of racemic alpha-lipoic acid on weight loss in a group of 360 overweight and obese men and women. 2020 Several supplements that may help in weight loss are under research worldwide to help treat overweight and obese people. 2018 Apr;37(2):419-428. doi: 10.1016/j.clnu.2017.06.002. Alpha lipoic Acid (ALA) ALA is a naturally formed substance made in every cell of our body. A significant overall mean BMI difference of -0.43 kg/ m 2 (confidence interval = -0.82 to … This site needs JavaScript to work properly. Time will only tell what added benefits researchers will track down proving the positive help alpha lipoic acid gives individuals around the world. ALA has been used in supplement form to help in the treatment of diabetes, HIV, cancer, liver ailments, and has recently gained more popularity in the use of weight loss. This added substance is giving individuals a boost when they need it the most, from something that is made within the human body already. Alpha lipoic acid (ALA) is a fatty acid that occurs naturally in the body and serves vital functions at the cellular level, such as energy production. To further clarify earlier ALA findings, researchers launched a 10-week study. The participants were assigned to one of three groups. It serves vital functions at the cellular level, such as energy production. These include Amanita mushroom poisoning, glaucoma , kidney disease , migraines , and peripheral arterial disease. Mean BMI differences between ALA…, Figure 3. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. She graduated with a bachelor‚Äôs degree in laboratory sciences from Helsinki Polytechnic in 2002 and is currently working on her doctoral degree in cell and molecular biology. Carbonelli, et al. The purpose of this study is to conduct a meta-analysis of the effect of ALA on weight and body mass index (BMI). Using Alpha Lipoic acid to address the weight issue in hypothyroidism is a tried and tested method. Alpha-lipoic acid does not generally cause serious side effects, according to a study published in "American Journal of Medicine". Keywords: According to studies, alpha-lipoic acid benefits health by helping to promote weight loss. It’s located in the hypothalamus in the brain and in high levels, it increases hunger. Mean body weight differences between ALA treatment and placebo, Figure 3. 2020 Jun;74(6):e13493. Obesity is a serious health condition that has been increasing considerably since the 1980s in the United States. Lipoic acid (often called α-lipoic acid), also known as thioctic acid, is a naturally occurring compound that is also synthesized by humans. 1997 Sep;46 Suppl 2:S62-6. Results: Body weight loss was significantly higher (P<0.05) in those groups supplemented with α-lipoic acid. Mean BMI differences between ALA treatment and placebo, NLM The material appearing on LIVESTRONG.COM is for educational use only. 2020 Sep 20;12(9):2873. doi: 10.3390/nu12092873. Antioxidants such as alpha lipoic acid can help neutralize and protect your body from those excess free radicals. These weight loss pills send 20% more glucose to away from fat cells and into muscle cells - which helps with weight loss and building muscle as more energy is used during exercise and less stored away as fat. Studies have suggested anti-obesity properties of ALA; however, results are inconsistent. ; 2003, American Journal of Medicine; Effects of Alpha-lipoic Acid on Body Weight..; E.H. Koh, et al. Leptin has also garnered quite a bit of interest in the field of weight loss studies. Further research is needed to examine the effect of different doses and the long-term benefits of ALA on weight management. Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, Tsouh Fokou PV, Azzini E, Peluso I, Prakash Mishra A, Nigam M, El Rayess Y, Beyrouthy ME, Polito L, Iriti M, Martins N, Martorell M, Docea AO, Setzer WN, Calina D, Cho WC, Sharifi-Rad J. How Alpha Lipoic Acid Influences Weight & Helps with Weight Loss The weight loss effects of ALA are likely due to multiple different factors. Always talk to your doctor before beginning to take dietary supplements. I typically recommend 3,000 mg EPA and DHA per day. (iv.111)However, currently there is considerable disagreement amongst researchers about the benefits of using antioxidant supplements with an exercise program. Copyright ©  |  eCollection 2019. Supplementation with lipoic acid transiently increases plasma and cellular concentratio… Alpha-lipoic acid has been used in alternative medicine as a possibly effective aid in weight loss, treating diabetic nerve pain, healing wounds, lowering blood sugar, improving skin discoloration caused by vitiligo, and decreasing complications of coronary artery bypass graft (CABG) surgery. doi: 10.2337/diab.46.2.s62. EPA supplementation significantly attenuated (P<0.001) the decrease in leptin levels that occurs during weight loss. (More information) 2. Alpha Lipoic Acid is hydrophilic and lipophilic (amphipathic), which allows it to reach every part of cells, including the mitochondria. 1. Lipids, 49(12), 1193-201. In the group that took 1800 mg alpha-lipoic acid per day the effect was statistically significant. Obesity is associated with significant morbidity and mortality rates. Diabetes. A significant overall mean BMI difference of -0.43 kg/ m2 (confidence interval = -0.82 to -0.03) was found between the ALA and placebo groups. Alpha lipoic acid (ALA) is a fatty acid which is often referred to as the ‘universal antioxidant'. Front Physiol. Results: A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations. J Obes Metab Syndr. Eur J Endocrinol. Li N, Yan W, Hu X, Huang Y, Wang F, Zhang W, Wang Q, Wang X, Sun K. Clin Endocrinol (Oxf). In addition, many alternative practitioners contend that alpha-lipoic acid can prevent or treat a multitude of health conditions, including alcoholic liver disease, HIV, Alzheimer's disease, bipolar disorder, cardiac arrhythmia, high blood pressure, rheumatoid arthritis, premature labor, schizoph… The antioxidant works by stimulating the body's ability to convert food into energy and is water soluble. Terms of Use Privacy Policy A comprehensive, systematic literature search identified 10 articles on randomized, double-blind, placebo-controlled studies involving ALA. We conducted a meta-analysis of mean weight and BMI change differences between ALA and placebo treatment groups. Oxid Med Cell Longev. Epub 2012 Jul 25. Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials. Understanding the Associations between Dietary Antioxidants and Obesity. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Studies of alpha-lipoic acid examined its properties as a supplement to reduce the risk of cardiovascular disease and as a possible supplement for weight loss. The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus. Flow Chart Depicting Selection of Studies, Figure 2. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. 2020 Sep 1;150(9):2336-2345. doi: 10.1093/jn/nxaa203. Bobe G, Michels AJ, Zhang WJ, Purnell JQ, Woffendin C, Pereira C, Vita JA, Thomas NO, Traber MG, Frei B, Hagen TM. eCollection 2020. Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. “But people who lost weight on lipoic acid also reduced their blood triglyceride levels – that effect was clear.” Other effects of the lipoic acid supplements were measurable as well. NIH Studies have noticed that it may reduce enzyme AMP-activated protein kinase (AMPK) activity. Doctor’s Best Alpha-Lipoic Acid (600 mg): This is a high-dose alpha-lipoic acid supplement that sells for around $0.16 per capsule. . Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Have you heard about ALA? The weight-loss enhancing ability of alpha lipoic acid has been put to the test in human studies as well. Source: 1 “Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.” Obesity (Silver Spring). any of the products or services that are advertised on the web site. It should not be It is responsible for converting glucose to energy. COVID-19 is an emerging, rapidly evolving situation. “The effect of lipoic acid supplements on blood lipids was limited,” said Gerd Bobe, another LPI scientist who collaborated on the study. A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. 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